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Phytochemical Screening and In Silico Analysis of Some Crude Stem Extracts against Skin Diseases

Surbhi Dubey1 , Shweta Sao2

Section:Research Paper, Product Type: Journal Paper
Volume-07 , Issue-03 , Page no. 109-113, Feb-2019

Online published on Feb 15, 2019

Copyright © Surbhi Dubey, Shweta Sao . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IEEE Style Citation: Surbhi Dubey, Shweta Sao, “Phytochemical Screening and In Silico Analysis of Some Crude Stem Extracts against Skin Diseases,” International Journal of Computer Sciences and Engineering, Vol.07, Issue.03, pp.109-113, 2019.

MLA Style Citation: Surbhi Dubey, Shweta Sao "Phytochemical Screening and In Silico Analysis of Some Crude Stem Extracts against Skin Diseases." International Journal of Computer Sciences and Engineering 07.03 (2019): 109-113.

APA Style Citation: Surbhi Dubey, Shweta Sao, (2019). Phytochemical Screening and In Silico Analysis of Some Crude Stem Extracts against Skin Diseases. International Journal of Computer Sciences and Engineering, 07(03), 109-113.

BibTex Style Citation:
@article{Dubey_2019,
author = {Surbhi Dubey, Shweta Sao},
title = {Phytochemical Screening and In Silico Analysis of Some Crude Stem Extracts against Skin Diseases},
journal = {International Journal of Computer Sciences and Engineering},
issue_date = {2 2019},
volume = {07},
Issue = {03},
month = {2},
year = {2019},
issn = {2347-2693},
pages = {109-113},
url = {https://www.ijcseonline.org/full_spl_paper_view.php?paper_id=688},
publisher = {IJCSE, Indore, INDIA},
}

RIS Style Citation:
TY - JOUR
UR - https://www.ijcseonline.org/full_spl_paper_view.php?paper_id=688
TI - Phytochemical Screening and In Silico Analysis of Some Crude Stem Extracts against Skin Diseases
T2 - International Journal of Computer Sciences and Engineering
AU - Surbhi Dubey, Shweta Sao
PY - 2019
DA - 2019/02/15
PB - IJCSE, Indore, INDIA
SP - 109-113
IS - 03
VL - 07
SN - 2347-2693
ER -

           

Abstract

Curcumin is an important phytochemical present in curcuminoids (rhizome plants) essential; for control of skin diseases. The phytochemicals are more in Zingiber officinale followed by Aloe barbadensis, Curcuma longa and Curcuma angustifolia. Amino acids, Proteins, carbohydrates, tanins and terpenoids were almost present in all the selected plants. The plant Curcuma angustifolia aqueous extract has good composition of terpinoids and analysed for in silico studies of Curcumin with Staphylococcus aureus, Streptococcus pyogenes and Trichophyton rubrum proteins. Curcumin has shown good binding affinity with streptococcal superantigen (SSA) from Streptococcus pyogenes (-90.62 KCal/Mol) followed by exfoliative toxin B in Staphylococcus aureus (-85.01 KCal/Mol) and Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum (-82.96 KCal/Mol). Curcumin has shown good in silico activities against proteins/ antigens for skin diseases. Further isolation and identification through wetlab studies provide good scope in the field of phytochemistry

Key-Words / Index Term

Phytochemical screening, in silico studies, curcumin

References

[1] B. R David, H. W. Lim, D. Margolis, M. A. Weinstock, C. Goodman, E. Faulkner, C. Gould, E. Gemmen, T. Dall, "The burden of skin diseases: 2004: A joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology", Journal of the American Academy of Dermatology, Vol. 55, No. 3, pp. 490-500, 2006.
[2] J. M. McGinnis, P. Williams-Russo, J. R. Knickman, “The case for more active policy attention to health promotion”, Health affairs, Vol. 21, No. 2, pp. 78-93, 2002.
[3] K. P. High, S. F. Bradley, S. Gravenstein, D. R Mehr, V. J. Quagliarello, C. Richard, T. T. Yoshikawa, “Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America”, Clinical Infectious Diseases, Vol. 48, No. 2, pp. 149-171, 2009.
[4] R.N.S. Yadav, Munin Agarwala, "Phytochemical analysis of some medicinal plants." Journal of phytology, Vol. 3, No. 12, pp. 10-14, 2011.
[5] A. Wadood, M. Ghufran, S.B. Jamal, M. Naeem, A. Khan, R .Ghaffar, “Phytochemical Analysis of Medicinal Plants Occurring in Local Area of Mardan”, Biochem Anal Biochem, Vol. 2, pp. 144, 2013.
[6] N. P. Peteros, M. M. Uy, “Antioxidant and cytotoxic activities and phytochemical screening of four Philippine medicinal plants”, Journal of Medicinal Plants Research, Vol. 4, No. 5, pp. 407-414, 2010.
[7] W. F. Sule, I. O. Okonko, S. Omo-Ogun, J. C. Nwanze, M. O. Ojezele, O. J. Ojezele, J. A. Alli, E. T. Soyemi, T. O. Olaonipekun. "Phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract", Journal of medicinal plants research, Vol. 5, No. 2, pp. 176-183, 2011.
[8] I. Chattopadhyay, K. Biswas, U. Bandyopadhyay, R. K. Banerjee, “Turmeric and curcumin: Biological actions and medicinal applications”, CURRENT SCIENCE-BANGALORE, Vol. 87, pp.44-53, 2004.
[9] R. Aly, “Microbial Infections of Skin and Nails. In: Baron S, editor. Medical Microbiology”, 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston, Chapter 98, 1996.
[10] E. Kunchandy, M.N.A. Rao, “Oxygen radical scavenging activity of curcumin”, International Journal of Pharmaceutics, Vol. 58, No. 3, pp. 237-240, 1990.
[11] C. Y. Hsieh, “Phase I clinical trial of curcumin, a chemopreventive agent, in patients with highrisk or pre-malignant lesions”, Anticancer Res, Vol. 21, pp. 2895-2900. 2001.
[12] P. Anand, A.B. Kunnumakkara, R.A. Newman, B. B. Aggarwal, “Bioavailability of curcumin: problems and promises”, Molecular pharmaceutics, Vol. 4, No. 6, pp. 807-818, 2007.
[13] B.B Aggarwal, A. Kumar, A.C. Bharti, “Anticancer potential of curcumin: preclinical and clinical studies”, Anticancer research, Vol. 23, No.1/A, pp. 363-398, 2003.
[14] S. A Jatoi, A. Kikuchi, S.A. Gilani, K. N. Watanabe, “Phytochemical, pharmacological and ethnobotanical studies in mango ginger (Curcuma amada Roxb.; Zingiberaceae)”, Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, Vol. 21, No. 6, pp. 507-516, 2007.
[15] S.V.G.K.D. Kaladhar, G.R. Duddukuri, K. Ramesh, V. Vadlapudi, N.S. Yarla, “In Vitro Protease Inhibition, Modulation of PLA2 Activity and Protein Interaction Studies on Calotropis gigantean”, Journal of Clinical & Cellular Immunology, Vol. 4, pp. 165, 2013.